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Date : 2008-12-12
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Clostridial Neurotoxins Mechanism of SNARE Cleavage and ~ The clostridial neurotoxin family consists of tetanus neurotoxin and seven distinct botulinum neurotoxins which cause the diseases tetanus and botulism The extreme potency of these toxins primarily relies not only on their ability to specifically enter motoneurons but also on the activity their catalytic domains display inside presynaptic motoneuronal terminals
Structural basis of cell surface receptor recognition by ~ One of two papers that describe how botulinum toxins produced by Clostridium botulinum are potent inhibitors of neurotransmitter release by elucidating the crystal structure of botulinum toxin B
Structural analysis of Clostridium botulinum neurotoxin ~ The botulinum neurotoxin type D is one of seven highly potent toxins produced by Clostridium botulinum which inhibit neurotransmission at cholinergic nerve terminals A functional fragment derived from the toxin LHn consisting of the catalytic and translocation domains has been heralded as a platform for the development of targeted secretion inhibitors
Reengineering the target specificity of clostridial ~ In this paper the production of a fully recombinant fusion protein from a recombinant gene encoding both the LH N domain of a clostridial neurotoxin and a specific targeting domain is described together with the ability of such recombinant fusion proteins to inhibit secretion from nonneuronal target cells
New insights into clostridial neurotoxin–SNARE ~ The clostridial neurotoxin CNT family of structurally and functionally related toxins includes the BoNT serotypes A–G and tetanus neurotoxin TeNT The Zn 2 binding HisGluXXHis motif that was identified in CNT primary structures immediately indicated that they might use a Zn 2 dependant proteolytic activity in their biochemical mechanism of action 8
Crystal structure of Clostridium botulinum neurotoxin ~ Clostridium botulinum neurotoxins BoNTs the most potent toxins known disrupt neurotransmission through proteolysis of proteins involved in neuroexocytosis The light chains of BoNTs are unique zinc proteases that have stringent substrate specificity and require exceptionally long substrates
Structural basis of cell surface receptor recognition by ~ In addition to providing structural insights into receptor recognition by BoNTB this study provides a molecular basis for studying other potential neurotoxinreceptor interactions
PDF Reengineering the target specificity of Clostridial ~ Reengineering the target specificity of Clostridial neurotoxinsA route to novel therapeutics The ability to chemically couple proteins to LHNfragments of clostridial neurotoxins and create novel molecules with selectivity for cells other than the natural target cell of the native neurotoxin is well established
PDF Clostridial Neurotoxins Mechanism of SNARE Cleavage ~ Clostridial Neurotoxins Mechanism of SNARE Cleavage and Outlook on Potential Substrate Specificity Reengineering The clostridial neurotoxin family consists of tetanus neurotoxin and seven distinct botulinum neurotoxins which cause the diseases tetanus and botulism
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